Fig. 2.

The effect of norfloxacin and moxifloxacin on melanin content (a) and tyrosinase activity (b) in melanocytes. Cells were cultured with norfloxacin or moxifloxacin in concentrations from 0.005 to 0.5 mM for 24 h. The melanin content and cellular tyrosinase activity were measured as described in “Materials and methods” section. Results are expressed as percentages of the controls. Data are mean ± S.E.M. of at least three independent experiments (n = 3) performed in triplicate. * p < 0.05 versus the control samples; ** p < 0.005 versus the control samples