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. 2015 Jan 27;10:609–631. doi: 10.2147/IJN.S71198

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© 2015 Vasconcelos et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Cytotoxicity of PLGA-PEG-peptide NPs on (A) HepG2 and (B) HeLa cells lines using the MTT assay, and photographs of (C) HepG2 and HeLa cells incubated with NPs to LD₅₀ and LD₁₀₀ concentrations.

Abbreviations: HIV-Tat, human immunodeficiency virus transactivator; LD₅₀, median lethal dose; LD₁₀₀, lethal dose; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium; NPs, nanoparticles; PEG, polyethyleneglycol; PLGA, poly(lactic-co-glycolic acid); POD, peptide for ocular delivery.