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. 2015 Feb 3;10(2):e0117000. doi: 10.1371/journal.pone.0117000

Figure 1. The Tsc1fl/fl;AlbCre;S6k1-/- mice develop normally and have increased insulin sensitivity.

Figure 1

A) Total body weights of male littermates fed either NCD or HFD over the study period. *, p<0.05 comparing S6k1-/- with Tsc1-/-. B) Box-and-whisker plots of liver weights (absolute and relative) and epididymal white adipose tissue weights following 8 weeks of NCD or HFD. *, p<0.05 compared to NCD within genotype, **, p<0.05 compared to control within diet. C) Glucose tolerance and insulin sensitivity tests. *, p<0.05 comparing Tsc1-/-;S6k1-/- to control. D) Fasting blood glucose and plasma insulin levels 30 minutes following glucose administration. N = 4–7 mice per group.