Figure 7.

Effect of HCV Core substitutions on minimum VLXT scores. Mutant HCV core proteins from Figures 5 and 6 were analyzed for their propensity to form alpha helices using the VLXT algorithm. As an indication of the impact of the substitution on predicted helix formation, the minimum VLXT score within the predicted MoRF is plotted for each HCV Core MoRF1 (A) and Morf2 (B) variant. Substitutions that disrupted binding of all three cellular proteins (broadly disruptive) are indicated in red, whereas those that disrupted binding to one or two cellular proteins are shown in blue; substitutions that had no effect on binding are shown in white.