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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Neurobiol Aging. 2014 Nov 15;36(2):1045–1056. doi: 10.1016/j.neurobiolaging.2014.11.007

Figure 4. Age reduces olfactory sensory neurons in the OE and olfactory bulb.

Figure 4

(A) Representative immunoreactivity to olfactory marker protein (OMP), a marker of mature olfactory sensory neurons, in the OE of IP3R3+/− mice at 2, 6, and 24 months. Dashed line marks the basement membrane. Scale bar = 10 µm. (B) The volume density of OMP+ neurons was significantly reduced in the OE of IP3R3+/− at 12 and 24 months. * p < 0.001 at 24 vs. 2, 6 and 12 months and p < 0.01 at 12 vs. 6 months (one-way ANOVA followed by Newman-Keuls post-hoc test; n = 3–6 mice per group). (C–D) Low (C–D) and high (C’, D’) magnification images depicting representative immunoreactivity to OMP in the olfactory bulb of IP3R3+/− mice at 2 (C, C’) and 24 (D,D’) months. Regions of higher magnification indicated by outlined region (white box). Nuclei were counterstained with DAPI. Dashed line marks the boundary between olfactory nerve layer (ONL) and glomerular layer (G). Scale bar = 50 µm.