Figure 6.

Plasma receptor-interacting serine/threonine-protein kinase 3 (RIP3) levels in septic subjects are higher among patients who are transfused and nonsurvivors. (A) Box-and-whisker plots of RIP3 levels at Day 2 for patients with sepsis who were transfused (n = 19) versus never transfused (n = 18). The median RIP3 in nontransfused patients was 358.7 pg/ml versus 2,692.0 pg/ml in the transfused patients (P = 0.046.) RIP3 levels at (B) Day 0 and (C) Day 2 in patients with sepsis classified by survival (survivors, n = 12; nonsurvivors, n = 25). Levels were compared by Wilcoxon rank sum test. Boxes display medians with interquartile ranges; error bars indicate 10th to 90th percentiles.