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. 2014 Dec 1;190(11):1243–1254. doi: 10.1164/rccm.201406-1095OC

Figure 8.

Figure 8.

High-mobility group box 1 (HMGB1) mediates enhanced lung inflammatory responses following red blood cell (RBC) transfusion. (A) Bronchoalveolar lavage (BAL) KC and MIP-2 following transfusion alone, KC P = 0.71, MIP-2 P = 0.90. (B) BAL KC and MIP-2 following LPS injection, both *P < 0.01. Data represents two independent studies, n = 6 mice per group (for A and B). (C) BAL chemokines (KC *P < 0.01 and MIP-2 P = 0.35). Data represents five independent studies, n = 14–16 mice per group. (D) Transfusion with isotype antibody control increases BAL KC and MIP-2 (*P < 0.01 and *P = 0.03, respectively). Blockade of HMGB1 with blocking antibody attenuates BAL KC and MIP-2 (**P = 0.045 and **P = 0.037, respectively). Data represent three independent studies, n = 10–12 mice per group. KC = keratinocyte chemoattractant; MIP = macrophage inflammatory protein 2; PBS = phosphate-buffered saline.