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. 2015 Feb 4;35(5):1921–1938. doi: 10.1523/JNEUROSCI.3207-14.2015

Figure 1.

Figure 1.

Recombinant HIV-1 Tat reduces detectable LC3II and SQSTM1 levels in neuronal cells. A, Immunoblot specific for LC3, SQSTM1, and actin using lysates from B103 rat neuroblastoma cells treated with increasing doses (10 ng/ml, 100 ng/ml, or 500 ng/ml) of Tat for 24 h. B, Densitometry analysis of LC3II immunoblot in B103 rat neuroblastoma cells. C, Densitometry analysis of SQSTM1 immunoblot in B103 rat neuroblastoma cells. D, LC3 immunoblot of lysates from primary mouse neurons treated with 100 ng/ml or 500 ng/ml Tat for 24 h. E, Densitometry analysis of LC3II bands in primary mouse neurons. F, Densitometry analysis of SQSTM1 bands in primary mouse neurons. Statistical significance: *p < 0.05, **p < 0.01, one-way ANOVA, post hoc Fisher's test.