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. 2015 Feb 4;35(5):2133–2145. doi: 10.1523/JNEUROSCI.4098-14.2015

Figure 6.

Figure 6.

B-cell-deficient muMT mice do not develop either LTP or cognitive deficits in the weeks after stroke. A, B, Whole-cell EPSCs were recorded from CA1 pyramidal neurons in acute hippocampal slices prepared from WT and muMT mice that had undergone DH stroke or sham surgery 12 weeks earlier (n = 6–9 per group). The time course (A) and magnitude (B) of LTP demonstrated that muMT mice that had undergone DH stroke did not develop an LTP impairment 12 weeks following stroke. *p < 0.05, compared with WT sham control. There was no difference between sham groups (p = 0.85). LTP plot represents 0–40 min after LTP. Values in the bar graph were taken at 35 min after LTP. C, muMT mice also did not develop a cognitive deficit on the OLT test 7 weeks after DH stroke (n = 10 per group). *p < 0.05, compared with unmoved objects. D, WT, but not muMT, mice developed a cognitive deficit on the Y maze 7 weeks after DH stroke (n = 10 per group). *p < 0.05, compared with sham.