Table 2.
Spinal intact | SCI 1 week | SCI 1 week + chronic TrkB-Ig2 | SCI 4 weeks | SCI 4 weeks + chronic BDNF (0.7 μg/d) | |
---|---|---|---|---|---|
Mean neurite length (μm) | 1723.3 ± 140.3 | 1545.7 ± 153.3* | 2307.3 ± 192.7# | 1892.9 ± 138.2 | 2020.4 ± 153.3 |
Mean soma area (μm2) | 1383.0 ± 152.2 | 1188.2 ± 67.9 | 976.8 ± 70.1+ | 1237.4 ± 67.9++ | 1002.7 ± 39.2 |
Spinal lesion resulted in a decrease in growth ability as neurites were shorter 1 week after SCI compared with spinal intact rats (*p < 0.05 vs spinal intact). BDNF sequestration potentiated cell growth as cells from 1 week SCI animals treated with TrkB-Ig2 presented longer neurites, compared with nontreated animals at the same time point (#p < 0.05 vs SCI 1 week). In what concerns the soma area, DRG neurons from 1 week SCI animals treated with TrkB-Ig2 had slightly smaller cell bodies compared with nontreated SCI rats at the same time point (+p < 0.05 vs SCI 1 week). Four week SCI animals presented an increase of the soma area compared with other experimental groups (++p < 0.05 vs remaining groups).