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. 2015 Feb 4;35(5):2146–2160. doi: 10.1523/JNEUROSCI.0373-14.2015

Table 2.

Mean total neurite length (μm) and mean soma area (μm2) from cultured DRG cells from spinal-intact animals, 1 and 4 weeks SCI animals, 1 week SCI animals treated with chronic TrkB-Ig2, and 4 week SCI animals treated with chronic BDNF (0.7 μg/d)

Spinal intact SCI 1 week SCI 1 week + chronic TrkB-Ig2 SCI 4 weeks SCI 4 weeks + chronic BDNF (0.7 μg/d)
Mean neurite length (μm) 1723.3 ± 140.3 1545.7 ± 153.3* 2307.3 ± 192.7# 1892.9 ± 138.2 2020.4 ± 153.3
Mean soma area (μm2) 1383.0 ± 152.2 1188.2 ± 67.9 976.8 ± 70.1+ 1237.4 ± 67.9++ 1002.7 ± 39.2

Spinal lesion resulted in a decrease in growth ability as neurites were shorter 1 week after SCI compared with spinal intact rats (*p < 0.05 vs spinal intact). BDNF sequestration potentiated cell growth as cells from 1 week SCI animals treated with TrkB-Ig2 presented longer neurites, compared with nontreated animals at the same time point (#p < 0.05 vs SCI 1 week). In what concerns the soma area, DRG neurons from 1 week SCI animals treated with TrkB-Ig2 had slightly smaller cell bodies compared with nontreated SCI rats at the same time point (+p < 0.05 vs SCI 1 week). Four week SCI animals presented an increase of the soma area compared with other experimental groups (++p < 0.05 vs remaining groups).