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. 2014 Dec 12;4(12):e269. doi: 10.1038/bcj.2014.89

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Copyright © 2014 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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RNA sequencing shows a change in gene expression profile in BCR-ABL1⁺ pre-B cells. (a) Heat map of differentially expressed genes from RNA sequencing analysis of pre-B cells from BA and MIG control mice. (b) Gene set enrichment analysis of genes differentially expressed in (a) showing significant enrichment of different gene sets. (c) Using principal component analysis, the gene expression profile from BA and MIG pre-B cells were compared with those of B-cell populations from normal BM and childhood BCR-ABL1⁺ pre-B ALLs.