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. 2014 Apr 4;38(5):932–946. doi: 10.1111/1574-6976.12071

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© 2014 The Authors. FEMS Microbiology Reviews published by John Wiley & Sons Ltd on behalf of Federation of European Microbiological Societies.

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Fig 3 — Regulators controlling transcription of the cyl operon. The two-component system CovS/R represents the major regulator of haemolysis and pigmentation in GBS. In wild-type strains the response regulator CovR is phosphorylated through CovS and bound to the cyl promotor region. Binding of CovR results in a repression of cyl gene transcription. This repression is modulated by an inhibition of CovR through the serine threonine kinase Skt1 and an inhibition of CovS through the Abi domain protein Abx1. In addition, the RovS regulator as a stand-alone system can increase haemolysin and pigment expression through binding to the cyl promotor region.