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Effects of efavirenz (EFV) on cell injury and intracellular ATP concentrations in cultured mouse hepatocytes. Time course and concentration response of (A) LDH release and (B) intracellular ATP content after treatment with solvent (DMSO, 0.25%) or EFV (30, 40, or 50 µM). Data are mean±SD of three independent hepatocyte preparations using quadruplicate wells. *P<0.05 versus solvent control.
