Fig. 4.
Effects of Fe-TCP or Fe-TMPyP on EFV-induced superoxide anion and peroxynitrite generation in hepatocytes. Fe-TCP, a SOD mimetic, or Fe-TMPyP, a peroxynitrite decomposition catalyst, were used to demonstrate the selectivity of the assay for mitochondrial superoxide anion (mtO2−) and peroxynitrite (ONOO−) in hepatocytes exposed to EFV (50 µM) for 6 h. Data are mean±SD of three independent hepatocyte preparations using quadruplicate wells. *P<0.05 versus solvent control; #P<0.05 versus EFV alone.