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EFV-induced cell injury in hepatocytes isolated from Sirt3+/+ (WT) or Sirt3−/− (KO) mice. LDH release (A) and intracellular ATP content (B) were measured after treatment with solvent or EFV for 24 h. Data are mean±SD of three independent hepatocyte preparations using quadruplicate wells. *P<0.05 versus solvent control; #P<0.05 KO versus WT.
