Fig. 10.

Schematic representation of the putative mechanisms involved in EFV-mediated inhibition of mitochondrial complex I. The major consequences of complex I inhibition are alterations in the NADH/NAD⁺ balance and the generation of peroxynitrite stress, resulting in mitochondrial protein hyperacetylation and thiol oxidation, respectively. MOM, mitochondrial outer membrane; MIM, mitochondrial inner membrane; Q, ubiquinone; Ac−K, acetylated-lysine; ONOO⁻, peroxynitrite.