Fig. 2.

NLRP3 domain structure and its influence on interactions of its pyrin domain. (A) It is unresolved how the pyrin domains shielded from engaging the readily available pyrin domain in ASC in non-activated NLRP3. (B) Disease-associated mutations in NLRP3 were shown to promote pyrin–pyrin domain engagement between NLRP3 and ASC. (C) Biochemical deletion of the LRR-domain in NLRP3 unmasks the pyrin domain and thus facilitates its binding to ASC's pyrin domain.