Table 3.
UGT1A1 genotype |
Case group (n = 268) |
Control group (n = 441) |
P (χ2 test) | ||
Number | % | Number | % | ||
Wild type | 121 | 45.2 | 218 | 49.4 | 0.78 |
Heterozygous variation | 118 | 44.0 | 186 | 42.23 | |
6/71 | 37 | 96 | |||
211 G to A/normal | 76 | 79 | |||
1091 C to T/normal | 5 | 11 | |||
Compound heterozygous variation | 23 | 8.6 | 34 | 7.7 | |
6/7, 211 G to A/normal | 13 | 6 | |||
6/7, 686 C to A/normal | 8 | 20 | |||
6/7, 1091 C to T/normal | 0 | 2 | |||
6/7, 211 G to A/normal, | 1 | 2 | |||
686 C to A/normal 6/7, | |||||
686 C to A/normal, | 1 | 0 | |||
1091 C to T/normal | |||||
211 G to A/normal, | 0 | 4 | |||
1091 C to T/normal | |||||
Homozygous variation | 6 | 2.2 | 3 | 0.7 | |
7/72 | 1 | 0 | |||
211 G to A/211 G to A | 4 | 3 | |||
7/7, 211 G to A/normal | 1 | 0 |
6/7 and
7/7 represent A(TA)6TAA/A(TA)7TAA and A(TA)7TAA/A(TA)7TAA in the promoter area of UGT1A1 gene, respectively.
The expected frequency is 40.7% calculated by Hardy-Weinberg equilibrium: [2×(frequency of wild type)1/2×(frequency of compound heterozygous variation plus frequency of homozygous variation)1/2 = 2×49.41/2×(7.7+0.7)1/2 = 40.7]. The observed frequency (42.2%) is not significantly different from the expected frequency (40.7%) (P = 0.89 by χ2 test).