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. 2015 Feb 7;21(5):1595–1605. doi: 10.3748/wjg.v21.i5.1595

Figure 2.

Figure 2

Sequence chromatograms displaying concomitant mutations of KRAS and BRAF found in this study. Concomitant mutations of KRAS G12V (A) and BRAF R603stop were detected in colorectal carcinoma tissue of a 71-year-old woman (B). Another patient, a 62-year-old woman, had mutations of both KRAS G13D (C) and BRAF S602Y (D). The amino acid changes corresponding to the codon alternations are as follows: G12V (GGT→GTT) and G13D (GGC→GAC) in exon 2 of the KRAS gene, S602Y (TCT→TAT) and R603stop (CGA→TGA) in exon 15 of the BRAF gene.