Table 1.

Models of CVD disease prediction

	Framingham Risk Score (FRS) [10]	Atherosclerosis in communities (ARIC) [11]	Atherosclerosis in communities with c IMT measurement (ARIC IMT) [12]	HeartSCORE (SCORE) [13]	Reynolds Risk Score (RSS) [14,15]	QRisk2 [16]	PROCAM [17]
Derivation study	Framingham cohort	Atherosclerosis in communities cohort	Atherosclerosis in communities cohort	Pooled European cohorts	Pooled cohorts	Prospective nonrandomized database	MONICA cohort
Statistical method	Cox	Cox	Cox	Weibull / Cox	Cox	Cox	Weibull
Discrimination AUROC	0,733 to 0,788	0,695 to 0842	0,755	0,70 to 0,84	0,708 - 0,808	0,792	N/A
Sample size	8491	14054	14054	205178	27124	1535583	26975
Starting year	1968	1987	1987	1972	1992	1993	1978
Number of variables	8	9	10	6	8	14	9
Notoriety	Guideline	No	No	Guideline	No	No	No
Age of participants mean (extremes)	48,5 to 49.1 (30-75)	54 (45 to 64)	54 (45 to 64)	(19-80)	45 +	48,5 (35-75)	45,7 (20-78)
Outcome measured	CVD Hard	CVD	CVD	CVD Mortality	CVD hard	CVD	CVD Hard
RA specific	No	No	No	No	No	Yes	No
Ease of use	Clinical + lab	Clinical + lab	Clinical, lab, ultrasound	Clinical, Lab	Clinical, Lab	Clinical, Lab	Clinical, Lab
Country	US	US	US	Europe	US	UK	Germany
Calculator available	Yes	Yes	Yes	Yes	Yes	Yes	Yes
10 year risk estimates	percentage	percentage	percentage	percentage	percentage	percentage	percentage
Calculator risk categories	<5%, 5- 10%, 10-20%, >20%	<5%, 5- 10%, 10-20%, >20%	<5%, 5- 10%, 10-20%, >20%	<5%, 5-9%, 10-15% > 15%	<5%, 5- 10%, 10-20%, >20%	<5%, 5- 10%, 10-20%, >20%	<10%, 10-20%,>20%
RA Validation	yes	no	no	yes	yes	yes	yes