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RCAN1 decreases nitric oxide endothelial level. Calcineurin is an important up-regulator of nitric oxide endothelial synthase (eNOS). Activated eNOS will ensure a high NO concentration. NO is carried to tissues by cytoglobin (Cygb). When RCAN1 inhibits calcineurin, eNOS will also be inhibited. Consequently, NO production is lowered, a process which leads to vasoconstriction
