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. 2015 Feb 4;5:8229. doi: 10.1038/srep08229

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(a) Bright field images of hFibs undergoing reprogramming upon OSKM transduction. Cells within the white dashed line at day 7 indicate the appearance of epithelial morphology in hFib cultures. These cells grew to make bigger colony structure by day 14, eventually generating the iPSC like colony at day 21. picking the colony allowed us to establish the iPSC line. (b) Expression profile of indicated mRNAs at various time courses of hFib reprogramming. (c) Expression profile of PRC2 components (Ezh2, Suz12 and Eed) in human fibroblasts, day 21 reprogramming cultures and various human pluripotent cells.