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. 2014 Dec;1839(12):1416–1432. doi: 10.1016/j.bbagrm.2014.05.009

Fig. 9.

Fig. 9

Structures of flavonoid, catechol, tripartin, and pyrido[1,2-a]indole inhibitors of JmjC KDMs. Numerous flavonoid and catechol compounds have been identified as JmjC KDM inhibitors from high-throughput screening, including myricetin (73) and dopamine (76). Precise mode(s) of inhibition, however, are unclear. Tripartin (79) is an indanone-based natural product that was shown to inhibit KDM4. Pyrido[1,2-a]indoles have been recently reported to inhibit KDM4C via unknown mechanism(s).