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Structures of 'pan-KDM' inhibitors. Compounds 80 and 81 (as racemates) combine KDM1 inhibitor tranylcypromine 2 with the JmjC KDM inhibitors 4-carboxy-4′-carboxymethoxy-2,2′-bipyridine 51 and IOX1 54 respectively. These dual inhibitors induce cell growth inhibition and apoptosis in prostate and colon cancer cell lines, but not in noncancer mesenchymal progenitor cells.
