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Interaction of proteins with the integral scaffold tight junction (TJ) proteins, zonula occludens (ZO)-1, -2, and -3. ZO proteins carry 3 post-synaptic density 95/Drosophila disc large/zona-occludens (PDZ) domains, a Src homology-3 (SH3) domain, and a region of homology to guanylate kinase (GUK) from the side of the N-terminus. Several TJ proteins and cytoskeletal actin interact with the ZO proteins. JAM-A, junctional adhesion molecule-A.
