Figure 1.

The Core Response Network (CRN). The CRN organizes immediate, instinctive response to environmental challenges, prior to extensive cortical processing. It includes the autonomic nervous system (hypothalamus), the limbic emotional system (amygdala, hippocampus, septal region), the emotional motor system (portions of the basal ganglia, red nucleus, periaqueductal gray), and the reticular arousal systems. All these systems interact strongly through multiple feed-back and feed-forward connections, forming a complex dynamical system which can enter various discrete functional and dysfunctional states.