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. 2014 Dec 15;9(24):2164–2173. doi: 10.4103/1673-5374.147949

Figure 2.

Figure 2

A blocker of Src family kinases PP2 treatment increased white matter spared tissue after spinal cord injury.

(A) Histological studies with luxol fast blue staining performed on representative spinal cord sections harvested within the 5 mm lesion epicenter in rats treated with PP2, PP3 and DMSO (top: dorsal region; bottom: ventral region). (B) Densitometric analysis demonstrated increased white matter spared tissue at 28 days post-injury in rats treated with PP2 compared to PP3 and DMSO treatment (*P < 0.05, ***P < 0.001) (n = 3). One-way analysis of variance followed by Bonferroni post hoc test was used to determine the significant differences among samples studied (F(2,6) = 31.72, P = 0.0006). Error bars show the standard error of the mean (SEM). PP2: 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyramidine; PP3: 4-amino-7-phenylpyrazolo[3,4-d]pyramidine (the inactive analog of PP2); DMSO: dimethyl sulfoxide.