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. 2015 Jan 24;7(1):1. doi: 10.1186/s13221-014-0026-3

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© George et al.; licensee Biomed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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_VEGF PADS pharmacokinetics and biodistribution. a. Fluorescently labeled free VEGF or _VEGFPADS were administered by IV injection to C57/Bl6 mice. Plasma levels were determined by direct fluorescence quantitation and fit to a two-compartment pharmacokinetic model. b. _VEGFPADS had a slower plasma clearance rate than free VEGF, as was evidenced by lower levels in the urine at the end of the experiment c. Data represent the mean ± sd of four mice per group. *p = 0.03, Student’s t-test. d. ELP fusion significantly altered the biodistribution of VEGF, increasing its levels in the spleen and liver and reducing its levels in the kidney. *p <0.05, two-way ANOVA with post-hoc Bonferroni multiple comparison.