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. 2015 Jan 28;6(1):1. doi: 10.1186/s13293-014-0019-1

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© Kwekel et al.; licensee Biomed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Plots of individual miRNAs (microarray data) exhibiting sex and age differences in expression are shown ( n = 4 or 5). A, B, C, H, and I show middle to late age expressed miRNAs; D, E, F, and G show young age expressed miRNAs. E and I also show miRNAs exhibiting significant sex differences. Bars represent normalized intensity values per age group; blue and red colors represent male and female data, respectively. Asterisks indicate ages where sex difference in expression is statistically significant (t-test, FDR <5%).