Fig. 3.—

Dependence of signals of recent positive selection on PPI network distances. (A) Proportions of coselected genes over network distance of SPL in CEU, YRI, EAS, and three populations combined and normalized against the expected proportions assuming no coselection (dotted line). (B) The Z-score of coselection (left y axis) is plotted against SPL distances. The frequencies of pairwise interactions of the whole PPI network are plotted against SPL as a background histogram in light gray color. Lines in different colors represent different populations as described in figure 2. * stands for P-values < 0.05, ** < 0.01, and *** < 0.001.