Flotegatide uptake by atheroma in an Athero mouse detected by micro-PET.
Panel A. CTA of the aorta was performed with intravenous injection of contrast agent. Areas of high CT attenuation such as contrast filled lumen, calcified plaque and bone appear dark. Calcified atheroma in the aortic arch is shown in panel A.
Panel B.
18F-Flotegatide was injected by tail vein and PET-CT was performed in-vivo after euthanasia. Arrow represents region of the aortic arch with high tracer uptake.
Panel C. CTA and micro-PET images were coregistered manually and the arrow points to the overlap between the region containing atheroma visualized by CTA and the aortic arch with 18F-Flotegatide uptake.