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. Author manuscript; available in PMC: 2015 Feb 4.
Published in final edited form as: Curr Biol. 2005 Jun 21;15(12):1099–1107. doi: 10.1016/j.cub.2005.05.053

Figure 3. Developmental Loss of Light-Responsive Cells.

Figure 3

(A) Proportion of cells (mean ± SEM) that were light responsive before (control), during (carb.), and after (recovery) application of the gap-junction blocker carbenoxolone (10 μM) in P0–1 and P4–5 retinae. There was a 33% loss in light-responsive cells at P0–1 and a 44% loss at P4–5 during drug treatment.

(B) Typical examples of melanopsin expression in P0, P4, P14, and adult retinae. The scale bar represents 50 μm.

(C) The number of melanopsin-positive cells per mm2 retina (mean ± SEM) has been plotted against developmental age. An overproduction of melanopsin-positive cells in the early neonate was observed. There is a significant difference in the number of melanopsin-positive cells at P0 or P4 relative to P14 levels (one-factor ANOVA, F3,6 = 10.874, p < 0.01, and post hoc Fishers LSD test: P14 versus P0, p < 0.05; P14 versus P4, p < 0.01) but no significant difference in melanopsin expression between P14 and adult retinae (p > 0.05).