. Author manuscript; available in PMC: 2015 Feb 4.

Published in final edited form as: Free Radic Res. 2013 Oct 4;47(11):958–986. doi: 10.3109/10715762.2013.832239

Table 2.

Comparison of mouse and human studies on parameters of immunological chemistry and genotoxicology.

Parameter	Mouse (model system)	Human
Infiltration of neutrophils and macrophages	↑ [37] (acetic acid), [39] (TNBS) [38] (Il10^−/), [26,27] (H.h. Rag2^−/−), [104] (C.r)	↑ [1]
Induction of NADPH ox expression	↑ [27] (H.h. Rag2^−/−)	↑ [46,47]
Induction of XOR expression	↑ [27] (H.h. Rag2^−/−)	n.c. [53]
Induction of iNOS expression	↑ [37] (acetic acid), [39,77,97] (TNBS), [78,86] (DSS), [38] (Il10^−/−), [26,27] (H.h. Rag2^−/−)	↑ [53,73,74,93,94,96,98,99,268–270]
Induction of MPO expression	↑ [79] (DSS), [39,97] (TNBS), [26,27] (H.h. Rag2^−/−), [104] (C.r.)	↑ [53,110]
GSH content	↓ (transient) [111] (TNBS)	↓ [113,114]
Induction of GPx2 expression	↑ [117] (DSS), [117] (TNBS), [27] (H.h. Rag2^−/−)	↑ [114,117]
Nitrotyrosine	↑ [86] (DSS), [39,97] (TNBS) [29] (H.h. Rag2^−/−), [104] (C.r.)	↑ [53,73,74,95,96] ↑ (in serum) [29]
Chlorotyrosine	↑ [29] (H.h. Rag2^−/−), [104] (C.r.)	↑ (in serum) [29]
Nitrosative DNA deamination	dI ↑ [27] (H.h. Rag2^−/−)	n.a.
Oxidative DNA damage	↑ [61,168,175] (DSS), [168] (Il10^−/−); [167] (CD45RB^high CD4⁺ T cell→SCID transfer model), [32] (Ikkβ(EE)^IEC/Apc^+/ΔIEC) ↓ (transient) [27] (H.h. Rag2^−/−)	↑ [114,170]
Lipid-peroxidation-induced damage	↑ [175] (DSS) ↓ (transient) [27] (H.h. Rag2^−/−)	↑ [173,176–178] ↓ (in PBMC from CRC patients) [181]
Halogenation DNA damage	↑ [27] (H.h. Rag2^−/−)	Detected [29]
DSB and chromosomal rearrangements	↑ [168,207] (DSS), [168,207] (Il10^−/−), [57] (TNBS), [27] (H.h. Rag2^−/−)	↑ [208–212]

n.c., no change; n.a., data not available, CRC, colorectal cancer; C.r., Citrobacter rodentium; H.h., Helicobacter hepaticus