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. 2015 Feb 4;6:17. doi: 10.3389/fgene.2015.00017

Figure 1.

Figure 1

Representation of epidermal growth factor receptors family (EGFR/ErbB1, ErbB2, ErbB3, and ErbB4) showing the distribution of the main SNPs mutations in the extracellular domain, transmembrane region, and intracellular domain comprising the tyrosine kinase and autophosphorylation sites. Boxes represent functional domains: I, extracellular domain sub-region I; II, extracellular domain sub-region II; III, extracellular domain sub-region III; IV, extracellular domain sub-region IV. (Prickett et al., 2009; Yarden and Pines, 2012).