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. 2015 Feb 4;6:10. doi: 10.3389/fphys.2015.00010

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Copyright © 2015 Forés-Martos, Cervera-Vidal, Chirivella, Ramos-Jarero and Climent.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Copy number analysis of Chromosome 21. (A) Representation of genomic gain (blue) and deletion (red) frequencies on four different tumor types and median average of all tumors together. (B) Deletion frequency for the three major deleted regions (MDR) in breast cancer (BC), melanoma (ML), lung tumors (LT), and Wilms Tumor (WT) on HSA21. (C) Representation of the three MDR based on genomic localization and size with those genes and miRNAs that showed downregulation in the gene expression correlation analysis.