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. Author manuscript; available in PMC: 2015 Feb 4.
Published in final edited form as: Cell Cycle. 2007 Sep 4;6(23):2859–2868. doi: 10.4161/cc.6.23.5018

Figure 3.

Figure 3

The amino acid sequences of the TIR domains of human TLR8, murine TLR8, and murine MyD88. The sequences were identified with the SMART (simple modular architecture research tool) program (smart.embl-heidelberg.de/); and the alignment analysis was performed with the MegAlign program (DNASTAR, Inc.) using the ClustalW method. Box 1, Box 2 along with the BB loop, and Box 3 are framed, and residues of the BB loop are shown in red. The residues within the three boxes of human and murine TLR8 are shown in bold. βA, B, C, D, E and αA, B, C, D, E at the top indicate five β-strands and α-helices, respectively, of the secondary structure of the TIR domain. The Genbank accession numbers assigned to the sequences are NP_057694 for human TLR8, NP_573475 for murine TLR8, and NP_034981 for murine MyD88.

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