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TLR8 stimulation in neurons activates neither the transcription factor NFκB (A) nor AP-1 (B). ELISA assays for NFκB (p65) and AP-1 (phospho-c-Jun) transactivation using nuclear extracts from the cortical neurons treated with 100 μM R-848, 500 μM loxoribine, 10 ng/ml TNFα for the indicated times. Note the robust activation of both NFκB and AP-1 detected in macrophages in response to R-848 stimulation. Data is presented as the mean ± SEM (n = 3). *p < 0.05, Student's t-Test.
