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. Author manuscript; available in PMC: 2015 Feb 4.
Published in final edited form as: J Pharm Sci Pharmacol. 2014 Jun 1;1(2):87–100. doi: 10.1166/jpsp.2014.1013

Figure 1.

Figure 1

Dose dependent inhibition of RXRα- mediated transcriptional activity by ERG/ EWS-ERG. (a) Cos-1 cells were cotransfected with pSG5/mRXRα, pCRBPII RARE–Luc, pRLSV-40 and increasing amount of pSG5/ERG (b) Cos-1 cells were cotransfected with pSG5/mRXRα, pCRBPII RARE–Luc, pRLSV-40 and increasing amount of pSG5/EWS-ERG. At 24 hours of transfection 500nm 9-cis-retinoic acid was added and further incubated for 24 hours. The luciferase activity obtained was set at 100%. The values represent the average of three independent experiments with standard deviation. **p < 0.01 compared with controls.