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. 2015 Feb 4;9:22. doi: 10.3389/fncel.2015.00022

Figure 2.

Figure 2

Calpastatin deficiency impairs NSC proliferation in the SGZ. Representative images from hippocampal brain sections of Cast+/+ (A) and Cast−/− (B) mice, showing EdU-positive cells in green and nuclei, labeled with Hoechst 33342, in gray. Number of EdU-positive cells in the SGZ (C) and the GZ (D) of the hippocampus. Co-localization of EdU (E) or proliferating cell nuclear antigen (PCNA) (F), in red, with the transcription factor Sox2, in green; nuclei are labeled with Hoechst 33342, in blue. Scale bars: 40 μm for (A) and (B); 10 μm for the left panels of (E) and (F); 5 μm for the right panels of (E) and (F). Means ± SEM of at least 3 independent experiments. Two-tailed t-test, *p < 0.05 (significantly different from Cast+/+).