. Author manuscript; available in PMC: 2015 Feb 4.

Published in final edited form as: Reproduction. 2014 Apr 8;147(5):R153–R167. doi: 10.1530/REP-13-0583

Table 1.

Genetic and immunogenetic features of the CBA × DBA model

Strain	Origin	MHC	H2-T23 (Qa1)	H2-T18	MMTV-7	Known Features/mutations	Response to the male antigen H-Y
CBA/J	Cross between Bagg female and DBA male in 1920; selected for low incidence of mammary tumors	H-2 haplotype k	b	b	a	homozygous for the retinal degeneration allele Pde6b^rd1; causes blindness High frequency of renal tubulointerstitial lesions	Non-responder
DBA/2	Oldest of all inbred strains; produced by CC Little in 1909	H-2 haplotype d	b	c	a	Widely used strain; traits often contrasted with C57BL/6J Hearing loss CD94 deficient (DBA/2) Low incidence of atherosclerosis Eye abnormality used as model for glaucoma	Non-responder
Balb/c		H-2 haplotype d	b	c	b	Well known for susecptibiltiy to autoimmune encephalomyelitis (EAE) Widely used for the production of monoclonal antibodies.	Non-responder