Table 2.
Representative manipulations of CBA × DBA matings
| Baseline Resorption Rate* (%) | Manipulation (Injection unless noted) | Resulting Resorption Rate* (%) | References |
|---|---|---|---|
| Decreased resorption rate | |||
| 31 | Second pregnancy | 1 | (Chavez, et al. 1987) |
| 30-35 | Second pregnancy | 15 | (Gendron, et al. 1992) |
| 23 | Add normal Balb/c male to cage on day 6 of 1st pregnancy | 4 | (Baines, et al. 1994) |
| 23 | Add castrated Balb/c male to cage on day 6 of 1st pregnancy | 9 | (Baines, et al. 1994) |
| 23 | Add Balb/c male bedding to cage on day 6 of 1st pregnancy | 9 | (Baines, et al. 1994) |
| 30 | Specific Pathogen free room | 8 | (Hamilton and Hamilton 1987) |
| 20-35 | Balb/c male spleen cells prior to mating# | 5-15 | (Kiger, et al. 1985) |
| 35 | Balb/c male spleen cells prior to mating | 20 | (Clark, et al. 2008a) |
| 20-35 | Balb/c male spleen cells prior to mating | 10 | (Clark, et al. 2013) |
| 20-35 | Balb/c spleen cells pre- incubated with Balb/c seminal plasma prior to mating | 3 | (Clark, et al. 2013) |
| 20-35 | DBA spleen cells pre-incubated with Balb/c seminal plasma prior to mating | 10 | (Clark, et al. 2013) |
| 30 | Spleen cells from Balb/c × DBA recombinant inbred strains K,N,C prior to mating | 5-17 | (Kiger, et al. 1985) |
| 24 | CBA bone marrow-derived dendritic cells pulsed with lysate of DBA male spleen cells | 5 | (Blois, et al. 2004) |
| 24 | Anti CD11b antibody iv on day 6 | 12 | (Duclos, et al. 1994) |
| 27 | Anti- CD8 and anti- CD86 | 9 | (Jin, et al. 2005) |
| 24 | Anti- CD86 | 8 | (Zhao, et al. 2007) |
| 28 | Anti-CD86 | 7 | (Zhu, et al. 2005) |
| 20 | 5mg/kg Cyclosporin A | 3 | (Du, et al. 2007) |
| 27 | 5mg/kg Cyclosporin A | 16 | (Li, et al. 2009) |
| 27-30 | Adenovirus –driven overexpression of CTLA-4 day 5 | 12 | (Li, et al. 2009) |
| 23 | i.vag. injection TGF-β day 0.5 | 12 | (Clark, et al. 2008a) |
| 70 | Interleukin (IL) 10 from culture supernatant days 6,8,10 | 5 | (Chaouat, et al. 1995) |
| 35 | Tumor Necrosis Factor(TNF) inhibitor (Pentoxifillin) days 6,8,10 | 20 | (Chaouat, et al. 1995) |
| 35 | Anti γ-interferon early in gestation | 15 | (Chaouat, et al. 1995) |
| 35 | TNF inhibitor + anti γ-IFN early in gestation | 10 | (Chaouat, et al. 1995) |
| 46-55 | IL-3 days 6.5-10.5 | 19-28 | (Chaouat, et al. 1990) |
| 35-40 | Interferon-τ | 5-10 | (Chaouat, et al. 1995) |
| 43 | IL-2 daily for 10 day from 4 days prior to mating | 15 | (Chen, et al. 2013) |
| 31 | C57Bl/6 male spleen and thymus cells | 8 | (Chavez, et al. 1987) |
| 31 | DBA male spleen and thymus cells | 12 | (Chavez, et al. 1987) |
| 27 | T cells from anti-B7 treated non-pregnant mice on day 4 gestation | 11 | (Jin, et al. 2004) |
| 18-20 | CD4+ CD25+ T cells from day 14 CBA × Balb/c females on day 0-2 of pregnancy | ~0 | (Zenclussen, et al. 2005) (Wafula, et al. 2009) |
| 20 | CD4+ CD25+ T cells from day 14 CBA × Balb/c females on day 0-2 of pregnancy + anti CTLA4 day 0,3,6,9 pregnancy | ~0 | (Wafula, et al. 2009) |
| 29 | Fresh CD4+CD25+ T cells from non-pregnant CBA females day 1-4 of pregnancy | 19-22 | (Yin, et al. 2012) |
| 29 | In vitro expanded CD4+CD25+ T cells from non-pregnant CBA females day 1-4 of pregnancy | 10-12 | (Yin, et al. 2012) |
| 30 | 3 × 105 regulatory B cells day 0 of pregnancy | ~0 | (Jensen, et al. 2013b) |
| 20 | Lipopolysaccharide (LPS) 2 weeks before mating | 9 | (Baines, et al. 1996) |
| 20 | Complete Freund's Adjuvant 2 weeks before mating | 10 | (Baines, et al. 1996) |
| 43 | Flt-3$ 6 days before mating | 14 | (Chen, et al. 2013) |
| 29 | Anti Crry Ig | 10 | (Girardi, et al. 2006) |
| 29 | Anti C5a | 10 | (Girardi, et al. 2006) |
| 29 | C5a receptor antagonist peptide | 10 | (Girardi, et al. 2006) |
| 30 | Prevastatin | 10 | (Redecha, et al. 2009) |
| Increased resorption rate | |||
| 19 | Second experiment, same publication (change housing) | 37 | (Clark, et al. 1994) |
| 19 | Third experiment, same publication (change housing) | 45 | (Clark, et al. 1994) |
| 43 | TNF ~ day 5.5 | 52 | (Chaouat, et al. 1990) |
| 28 | TNF ~day 7 | 98 | (Chaouat 1994) |
| 43 | TNF ~9.5 | 88 | (Chaouat, et al. 1990) |
| 43 | TNF ~13.5 | 67 | (Chaouat, et al. 1990) |
| 28 | γ-IFN ~day 7 | 75 | (Chaouat 1994) |
| 30 | IL-2 ~day 7 | 65 | (Chaouat 1994) |
| 50 | Anti IL-10 days 6,8,10 | 80 | (Chaouat, et al. 1995) |
| 19 | Anti GMCSF day 7.5 | 38 | (Clark, et al. 1994) |
| ? | LPS on day 0.5 | 18 | (Clark, et al. 2008a) |
| 38 | LPS ~day 7 | 100 | (Chaouat, et al. 1990) |
| 28-30 | LPS ~day 7 | 55-58 | (Chaouat 1994) (Clark, et al. 2004) |
| 24 | Poly I :C | 65 | (Duclos, et al. 1994) |
| 30 | Balb/c × DBA recombinant inbred strains L,E | 50-62 | (Kiger, et al. 1985) |
| 10-23 | Sound stress for 24 hours on day 5.5 | 44 | (Prados, et al. 2011) |
| 10 | Sound stress for 24 hours on day 5.5 | 30 | (Arck, et al. 1999) |
| 33 | Anti CD25 antibody day 1 | 67 | (Chen, et al. 2013) |
| 10 | Anti- T cell receptor antibody day 5.5 | ~100 | (Arck, et al. 1997) |
| 11 | Anti-γδ T cell antibody day 8.5 | 44-48 | (Arck, et al. 1999) |
| 19 | Anti- CD8 antibody day 6.5 | 60 | (Clark, et al. 1994) |
| 45 | Anti- CD8 antibody day 6.5 | 78 | (Clark, et al. 1994) |
| 20 | CD4+ CD25+ T cells from day 14 CBA × Balb/c females on day 0-2 of pregnancy + anti PD1 day 0,3,6,9 pregnancy | ~30 | (Wafula, et al. 2009) |
| No change resorption rate | |||
| 25 | Prior delivery with Balb/c males 6 weeks before mating | (Baines, et al. 1996) | |
| 20 | Second pregnancy with rapid re-mating (seven days) after delivery | (Baines, et al. 1996) | |
| 20-35 | CBA male spleen cells 7 days prior to mating | (Clark, et al. 2013) | |
| 20-35 | DBA male spleen cells 7 days prior to mating | (Clark, et al. 2013) | |
| 20-35 | Non-pregnant female Balb/c spleen cells ip 7 days prior to mating | (Kiger, et al. 1985) | |
| 20-35 | Male Balb/b or Balb/k spleen cells ip 7 days prior to mating | (Kiger, et al. 1985) | |
| 27 | Balb/c spleen cells 8 weeks before mating | (Baines, et al. 1996) | |
| 20-35 | Balb/c spleen cells pre-incubated with DBA seminal plasma | (Clark, et al. 2013) | |
| 11 | Anti Vgamma1.1, Anti Vdelta 6 antibody day 5.5 | (Arck, et al. 1999) | |
| 30 | Spleen cells from Balb/c × DBA recombinant inbred Strains M,J,D | (Kiger, et al. 1985) | |