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. Author manuscript; available in PMC: 2015 Feb 4.
Published in final edited form as: Biochemistry. 2012 May 17;51(21):4263–4270. doi: 10.1021/bi2016926

Figure 2. Thermostabilizing mutations in PTDH.

Figure 2

Ribbon diagram of the thermostable PTDH variant that was used for structural studies showing the 16 thermostabilizing mutations. Two of the mutations (Glu-332→Asn and Cys-336→Asp) occur within the six carboxy-terminal residues that are not visible in the structures. Note that all of these mutations are distal to the active site.