Table 2.

Parameters for long-term extrapolation

Parameter	Mean value
Annual risk of MI in the no event state	0.019
Annual risk of stroke in the no event state	0.003
Risk of death in the no event state*	2.00
Risk of death in the non-fatal MI state*	6.00
Risk of death in the post-MI state*	3.00
Risk of death in the non-fatal stroke state*	7.43
Risk of death in the poststroke state*	3.00
Cost in the non-fatal MI state (€)†	15 656 (5836, 9558, 2971)
Cost in the post-MI state (€)†	4172 (332, 3421, 792)
Cost in the non-fatal stroke state (€)†	12 977 (15 262, 14 925, 1527)
Cost in the poststroke state (€)†	3506 (4237, 4336, 413)
Cost in the no-event state (€)†	1376 (253, 719, 243)
QALY weight in the non-fatal state age<69 years	0.8737
QALY weight in the non-fatal state age 70–79 years	0.8130
QALY weight in the non-fatal state age >79 years	0.7537
QALY decrement non-fatal MI state	0.0755
QALY decrement post-MI state	0.0755
QALY decrement non-fatal stroke state	0.1034
QALY decrement post-stroke state	0.1034

*HR versus standard mortality.

†Values for the UK, Germany and Brazil shown in parentheses.

MI, myocardial infarction; QALY, quality-adjusted life-year.