Distribution of pain intensity scores, assessed in CP/CPPS patients with the NIH-CPSI. NIH-CPSI sub-scores were assigned to three increasing pain levels, according to Wagenlehner et al (21) as follows: Mild pain, 0–7 points; moderate pain, 8–13 points; severe pain, 14–21 points. (A) Pain intensity distribution in the total patient population. (B) Pain intensity in patients affected by the inflammatory (IIIa) or non-inflammatory (IIIb) sub-categories of CP/CPPS. Data are shown at enrollment (V0), at the end of therapy (V6), and at follow-up time-points (V12, V18). CP/CPPS, chronic prostatitis/chronic pelvic pain syndrome; NIH-CPSI, National Institutes of Health Chronic Prostatitis Symptom Index.