Table I.

Association between EGFR mutations, ERCC1 and RRM1 mRNA expression, and patient clinical characteristics.

	EGFR			ERCC1			RRM1
Clinical features	Mutant (n)	Wild-type (n)	P-value	High (n)	Low (n)	P-value	High (n)	Low (n)	P-value
Gender			<0.001			0.898			0.088
Male	52	86		65	73		92	46
Female	74	45		57	62		67	52
Age, years			0.287			0.943			0.714
≥59	68	62		62	68		79	51
<59	58	69		60	67		80	47
Smoking history			<0.001			0.199			0.129
Yes	34	65		52	47		67	32
No	92	66		70	88		92	66
Tumor diameter, cm			0.282			0.687			0.292
≥5	56	67		60	63		72	51
<5	70	64		62	72		87	47
Lymph node metastasis			0.903			0.470			0.188
Yes	51	54		47	58		70	35
No	75	77		75	77		89	63
Clinical stage			0.203			0.339			0.577
I	50	42		40	52		59	33
II+III+IV	76	89		82	83		100	65

EGFR, epidermal growth factor receptor; ERCC1, excision repair cross-complementing protein 1; RRM1, ribonucleotide reductase subunit M1.