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. 2015 Jan 19;9(3):725–732. doi: 10.3892/etm.2015.2188

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Copyright © 2015, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Effect of KB on liver injury in LPS-induced septic mice (hematoxylin and eosin staining). Mice were challenged with LPS for 4 h and then treated with KB for 4 h. Histological analysis was performed. Compared with (A) the control group, (B) LPS-challenge induced hepatocyte arrangement irregularities and central vein congestion, as well as the infiltration of inflammatory cells into the tissue. (C) Administration of KB significantly decreased the granulocyte infiltration and inflammatory response. The figure is representative of at least three experiments performed on different days. (Magnification, ×400). KB, kukoamine B; LPS, lipopolysaccharide.