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. 2015 Jan 19;9(3):725–732. doi: 10.3892/etm.2015.2188

Figure 5.

Figure 5

Effect of KB on cytokine expression in LPS-induced septic mice. Mice were challenged with LPS for 4 h and then treated with KB for 4 h. TNF-α and IL-1β levels in the plasma and tissue homogenates were assayed 4 h after KB treatment using ELISA kits. The levels of TNF-α and IL-1β in the (A and B) plasma and (C and D) tissue homogenates were markedly elevated following LPS challenge compared with those in the control group. Following the administration of KB, the increases in the cytokine levels were significantly attenuated. Results are presented as the mean ± standard deviation. **P<0.01 compared with control mice. #P<0.05 compared with LPS mice. KB, kukoamine B; LPS, lipopolysaccharide; TNF-α, tumor necrosis factor α; IL-1β, interleukin-1β.