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. 2015 Jan 19;9(3):725–732. doi: 10.3892/etm.2015.2188

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Copyright © 2015, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Effect of KB on ICAM-1 and VCAM-1 expression in the livers of LPS-induced septic mice. Mice were challenged with LPS for 4 h and then treated with KB for 4 h. The expression of the cellular adhesion molecules ICAM-1 and VCAM-1 was determined by immunohistochemical stains 4 h after KB treatment. Following LPS stimulation, the expression of ICAM-1 and VCAM-1 in the liver tissue was significantly increased compared with that in the control; however, with the in vivo administration of KB, the expression of (A-C) ICAM-1 and (D-F) VCAM-1 decreased significantly. (A and D) control group; (B and E) LPS group; (C and F) LPS + KB group. (Magnification, ×400). KB, kukoamine B; LPS, lipopolysaccharide; ICAM-1, intercellular adhesion molecule-1; VCAM-1, vascular cell adhesion molecule-1.