FIGURE 5.

AMI-mediated alterations in striatal proteins involved in stress response and energy management. A, AMI-mediated alteration in the expression levels of striatal proteins associated with mutant huntingtin, mitochondrial functions, and stress responses measured using Western blot in HD mice as follows: B, wild-type HTT (wt HTT), C, HSP70; D, HSP90; E, PGC-1α; F, UCP2; G, VDAC; H, complex IV. I, AMI-mediated alteration in expression levels of striatal proteins associated with mutant huntingtin, mitochondrial functions, and stress responses measured using Western blot in WT mice as follows: J, wild-type HTT (wt HTT); K, HSP70; L, HSP90; M, PGC-1α; N, UCP2; O, VDAC; P, complex IV. Data from three animals of each group are expressed as means ± S.E. *, p ≤ 0.05; **, p ≤ 0.01; ***, p ≤ 0.001. (Control treatment, Con or WT; AMI treatment, AMI or WT-AMI.)